Introducing an affordable way to obtain quality kinetic binding data. Until now, real-time label-free biomolecular interaction studies have been out of reach for some labs due to limited budgets. Analyses may also have been outsourced leading to delays in accessing the data for ongoing studies. Our new compact, easy-to-use system, expands access to high quality data, making it available in your lab. Measurement of binding kinetics for antibody development and other applications are now within easy reach.
With a broad range of kinetic measurements, like binding affinity, association and dissociation rates (Ka and Kd), you can make informed decisions faster. The measurements are quantitative and calibrated to the mass of the adsorbed layer, while offering a dynamic range of 4 orders of magnitude in molecular weight. The low cost sensor chips can be used for single or multiplex measurements. The system is ideal for:
- Kinetic Characterization: Determine affinity rate constants
- Immunoassay Development: Assess antibody pairs, biotinylation, reagent QC
- Small molecule studies: Observe protein binding without the DMSO ‘bulk effect’
- Virology: Selectively capture biological nanoparticles
- And much more
Benchtop label-free reader
So easy to use, you can get started in a matter of hours!
The low cost and simplicity of operations makes this accessible to every researcher.
No need for dedicated personnel
No need to send samples out, or wait to get data from a shared facility.
- Publication quality data
- Lead optimization & validation
- Antibody selection
- Biologics QC
Get the data you need from your own bench!
No need to label molecules!
The admitted gold standard for label-free biomolecular measurements is Biacore, now part of GE LifeSciences. However, these systems tend to be expensive, for both instrument and consumables, and require a qualified person to operate, typically, someone trained in biophysics. As an alternative, we propose a simpler system, that can be operated by a regular laboratory scientist.
The iRiS Kinetics system is a versatile and affordable benchtop system for high-quality characterization of biomolecular interactions, with applications from R&D to QC labs.
One of the main attributes of the system is its ability to overcome the bulk effect, a background signal shift often seen when looking at the binding of small molecules from DMSO solutions. It can detect molecules as small as 250 MW. From start to finish, binding curves can be obtained in about 2 hours.
Perfect for the measurement of binding kinetics for antibody development, bioprocessing Quality Control. If you develop assays and need to select antibody pairs, this system is ideally suited as it can measure simultaneous curves for hundreds of proteins arrayed on the chip. Multiplex tests and microarrays are fully enabled by this label-free system. You can manually spot small arrays using specially coated chips, or larger arrays using a microarray spotter.
iRiS Kinetics MX-100
- Highly multiplexed (100s of probes),
- Highly sensitive (<250Da molecular weight),
kinetic binding measurements
We cover the entire range of biological analytes including proteins, nucleic acids, peptides, and small molecules On a compact, robust, low-cost, fully-automated, and easy-to-use research instrument with versatile and inexpensive consumables
- Fully automated
- Four tubes for samples
- Four bottles for wash, buer and waste.
- Minimum sample volume: 100 microliter
Iris microfluidic cartridges (patent pending)
Iris sensor chips (patent pending)